Pantoprazole sodium is the sodium salt form of a substituted benzimidazole with proton pump inhibitor activity. Generic pantoprazole is covered by most medicare and insurance plans, but some pharmacy coupons or cash prices may be lower. By blocking this pump, the production of acid is decreased, and this allows the stomach, small intestine and food pipe to heal. Hypersensitivity to pantoprazole or other proton pump inhibitors ppis. Pantoprazole, like other medications in this group, may interact with methotrexate when the two medications are used at the same time. Pantoprazole is predicted to decrease the exposure to voxilaprevir. Drug nutrient interactions table of common drugs and medications. Talk with your doctor if you are at risk of broken bones.
Pantoprazole sodium sesquihydrate is a white to offwhite crystalline powder and is racemic. Nutrientdrug interactions merck manuals professional edition. To assess the effect of the proton pump inhibitor pantoprazole on the pharmacokinetics of ethanol. Pantoprazole is also sometimes used along with antibiotics to. Drug interactions are reported among people who take pantoprazole and methotrexate together. The risk is higher if you are older than age 50, use pantoprazole for more than a year, or take high doses of pantoprazole. Pantoprazole oral tablet is a prescription drug thats available as the brandname drug protonix. Handbook of drugnutrient interactions springerlink. In contrast to omeprazole, pantoprazole has a low potential to interact with the cytochrome p450 system in man. It helps heal acid damage to the stomach and esophagus, helps prevent ulcers, and may help prevent cancer of. Although there is a widespread public perception that herbs and botanical products in dietary supplements are safe, research has demonstrated that these products carry the same dangers. Iron salts also have the potential to interact with pantoprazole. This type of information is difficult to gather and to keep updated, because so many new drugs come out, and so many older drugs are pulled off the market.
Use of prescription or overthecounter drugs or medications shown to interfere with nutrient intake or use, to an extent that nutritional status is compromised. Table 4 includes drugs with clinically important drug interactions and interaction with diagnostics when administered concomitantly with protonix and instructions for preventing or managing them. Lansoprazole interactions bnf content published by nice. Pantoprazole is a proton pump inhibitor that decreases the amount of acid produced in the stomach pantoprazole is used to treat erosive esophagitis damage to the esophagus from stomach acid caused by gastroesophageal reflux disease, or gerd in adults and children who are at least 5 years old. Pantoprazole oral interactions with other medication. However, no formal drug interaction studies of methotrexate with ranitidine have been conducted.
You should make sure your doctor has a complete list of all medications, supplements, and herbal remedies you are taking, to avoid dangerous combinations. Heparin is an injectable drug used to prevent and treat blood clots in the veins, arteries, or lungs. Oct 24, 2018 protonix is supplied as a for delayedrelease oral suspension in unit dose packets, available in one strength 40 mg pantoprazole, equivalent to 45. The possibility of drug interactions, direct toxicities, and contamination with active pharmaceutical agents are among the safety concerns about dietary and herbal supplements.
To date, no drug drug interactions have been identified with pantoprazole in numerous. Consumer information about the otc and prescription drug omeprazole prilosec, zegerid prilosec otc, zegerid otc used for treating acidinduced inflammation and ulcers of the stomach and duodenum, gastroesophageal reflux disease gerd, heartburn, and zollingerellison syndrome. Sep 17, 2012 pantoprazole is a proton pump inhibitor ppi that binds irreversibly and specifically to the proton pump, thereby reducing gastric acid secretion. Other medications that may not be safely combined with pantoprazole are iron salts, ampicillin esters, ketoconazole, and warfarin. Jul 18, 2019 pantoprazole was detectable in milk only 2 and 4 hours after the dose with milk levels of approximately 36 mcgl and 24 mcgl, respectively. Pantoprazole therapy is associated with a low rate of transient and asymptomatic serum aminotransferase elevations and is a rare cause of clinically apparent liver injury. Drug category drug category brief description drug induced nutrient depletions additional suggested supplements for nutritional support dietary supplements that have potential for interactions with drug or drug class 7. This could potentially be a serious drug interaction.
Instruct patient to report bothersome or prolonged side effects, including headache or gi effects diarrhea, flatulence, belching, abdominal pain. Grapefruit interaction with cyclosporine a book called drug interactions went to press 35yrs ago and contained a few hundred drug. Pantoprazole is an inexpensive drug used to treat gastroesophageal reflux disease, inflammation of the esophagus, and zollingerellison syndrome. This combination may lead to higher than expected amounts of methotrexate in the body and can cause serious side effects, including kidney damage, irregular heartbeat, anemia, or infection. Botulinum toxin b increases intrinsic muscle activity in. Pantoprazole belongs to a class of drugs known as proton pump inhibitors ppis. Some research suggests that proton pump inhibitors ppis, like pantoprazole, may decrease the effectiveness of clopidogrel. For people taking pantoprazole, drug interactions may occur with warfarin and ampicillin esters.
However, experts are still in disagreement about how significant this interaction really is and whether it affects all ppis. Pantoprazole interactions bnf content published by nice. Pantoprazole has a relatively long duration of action compared with other ppis, and a lower propensity to become activated in slightly acidic body compartments. Mark this risk when a client is taking a drug or medication that can interfere with nutrient intake or use. Pantoprazole can reduce the absorption of other drugs due to its effect on reducing intragastric acidity. It works by decreasing the amount of acid your stomach makes.
Dailymed pantoprazole sodium tablet, delayed release. It works by decreasing the amount of acid produced by the stomach. Studies evaluating possible interactions of pantoprazole. Pantoprazole generic side effects usages composition. Do not confuse protonix pantoprazole with lotronex alosetron or protamine. Pantoprazole may increase your risk of having fractures of the hip, wrist, and spine. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is. Pantoprazole may increase the risk of broken bones in your spine, wrist, or hip. In the case of pantoprazole, drug interactions can occur with medications such as ketoconazole and ampicillin esters. Avoid food and drug interactions food and drug administration. Pantoprazole and methotrexate drug interactions a study of. In the drug interaction studies conducted so far, substrates for all relevant cytochrome p450 families involved in the metabolism of drugs in man were investigated. This medicine is available only with your doctors prescription.
Protonix, protonix iv pantoprazole oralinjection uses. Pantoprazole may cause low levels of magnesium in the blood. Drug interaction checker our drug interaction checker provides rapid access to tens of thousands of interactions between brand and generic drugs, overthecounter drugs, and supplements. Check mild interactions to serious contraindications for up to 30 drugs, herbals, and supplements at a time. Pantoprazole sodium drug interactions therapeutic effect of nelfinavir. Pantoprazole is a prescription drug used as a shortterm treatment for gastroesophageal reflux disease gerd its part of a class of medications known as. Pantoprazole springerlink clinical drug investigation. Consult the labeling of concomitantly used drugs to obtain further information about interactions with ppis. Some medications can interact negatively with pantoprazole. Drugs for which gastric ph can affect bioavailability 7. Effects of thymoquinone volatile oil of black cumin on rheumatoid arthritis in rat models article in phytotherapy research 219. This table lists common drugs that can affect nutrition status. Methotrexate systemic pantoprazole systemic major good concurrent use of methotrexate and pantoprazole may result in increased concentration of methotrexate and its metabolite and an increased risk of methotrexate toxicity.
The effect of drug on a person may be different than expected because that drug interacts with another drug the person is taking drugdrug interaction, food, beverages, dietary supplements the person is consuming drugnutrientfood interaction or another disease the person has drugdisease interaction. Do not take protonix if you are allergic to pantoprazole or any ingredients contained in this drug. Pantoprazole was detectable in milk only 2 and 4 hours after the dose with milk levels of approximately 36 mcgl and 24 mcgl, respectively. Drug interactions are reported among people who take pantoprazole and marijuana together. Effects of thymoquinone volatile oil of black cumin on. Pantoprazole is used to treat erosive esophagitis damage to the esophagus from stomach acid caused by gastroesophageal reflux disease, or gerd in adults and children who are at least 5 years old. Pantoprazole oral route description and brand names. Advise patient to avoid alcohol and foods that may cause an increase in gi irritation. Nonalcoholic, healthy volunteers four female, 12 male, age range. Pantoprazole is usually given for up to 8 weeks at a time while your esophagus heals. This interaction has also been reported in postmarketing period.
Protonix pantoprazole is a proton pump inhibitor that decreases the amount of acid produced in the stomach protonix is used to treat erosive esophagitis damage to the esophagus from stomach acid caused by gastroesophageal reflux disease, or gerd in adults and children who are at least 5 years old. Much of the information on this page came from ross peltons druginduced nutrient depletion handbook, because he posted it on the nutrition science news website, before they folded in 2002. Provides a summary of interactions with vitamins, herbs, and food. Important drug interactions for immunesuppressing and cancer drug methotrexate hide all summaries january 2020 patients taking the commonly prescribed drug methotrexate, which is used to treat certain autoimmune diseases and several types of cancer, should be aware that it has clinically important interactions with many other prescription and overthecounter medications. Handbook of drug nutrient interactions, second edition is a comprehensive uptodate text for the total management of patients on drug andor nutrition therapy but also an insight into the recent developments in drug nutrition interactions which will act as a reliable reference for clinicians and students for many years to come. Pantoprazole protonix side effects, dosage, interactions. To exclude intrinsic changes in muscle activity over the period of investigation, the drug. However, one study clearly showed a lack of interaction between pantoprazole and warfarin.
Lansoprazole is predicted to decrease the exposure to ledipasvir. Intrinsic muscle activity in nervemuscle cocultures was recorded on three subsequent days div 10. If the client is taking a drug or medication that isnt on this list, check the food medications interactions book for possible side effects. Foods can enhance, delay, or decrease drug absorption. In case of overdose, get medical help or contact a poison control center immediately. However, experts are still in disagreement about how significant this interaction really is and whether it. This medication relieves symptoms such as heartburn, difficulty swallowing, and persistent cough. On application of dips scale for drugdrug interaction, this case scored 5 points which shows that interaction between pantoprazole and warfarin is probable and caused a rise in inr. This is more likely if you take several doses per day or use it for one year or more. Pantoprazole is used to treat certain stomach and esophagus problems such as acid reflux. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Manufacturer advises adjust dose, see sofosbuvir with velpatasvir and voxilaprevir.
Pantoprazole belongs to the family of medications called proton pump inhibitors ppis. In patients with mild to moderate hepatic impairment, little drug accumulation has been observed following once. In this guide, a fooddrug interaction is a change in how a medicine works caused by food, caffeine, or alcohol. How to use protonix read the medication guide provided by your pharmacist before you start taking pantoprazole and. Handbook of drugnutrient interactions nutrition and. Pantoprazole is a substituted benzimidazole and proton pump inhibitor with antacid activity. This study is created by ehealthme based on reports of 7,811 people who take pantoprazole and methotrexate from food and drug administration fda, and is updated regularly. Abilify, seroquel, zyprexa, risperdal, invega, geodon, haldol, prolixen and others. Pantoprazole is a proton pump inhibitor ppi and a potent inhibitor of gastric acidity which is widely used in the therapy of gastroesophageal reflux and peptic ulcer disease. Coadministration of pantoprazole sodium in healthy subjects and in transplant patients receiving mmf has been reported to reduce the exposure to the active metabolite, mycophenolic acid mpa, possibly due to a. At the beginning of each recording session, contrast and brightness of the video image were optimized and a single picture was taken and stored on the computer. Protonix is supplied as a for delayedrelease oral suspension in unit dose packets, available in one strength 40 mg pantoprazole, equivalent to 45.
This drug is slightly more popular than comparable drugs. Pantoprazole, sold under the brand name protonix among others, is a medication used for the treatment of stomach ulcers, shortterm treatment of erosive esophagitis due to gastroesophageal reflux disease gerd, maintenance of healing of erosive esophagitis, and pathological hypersecretory conditions including zollingerellison syndrome. Lansoprazole decreases the absorption of ketoconazole. Handbook of drugnutrient interactions, second edition is a comprehensive uptodate text for the total management of patients on drug andor nutrition therapy but also an insight into the recent developments in drug nutrition interactions which will act as a reliable reference for clinicians and students for many years to come. Drug category drug category brief description druginduced nutrient depletions additional suggested supplements for nutritional support dietary supplements that have potential for interactions with drug or drug class 7. This medicine may cause hypomagnesemia low magnesium in the blood. This study is created by ehealthme based on reports of 99 people who take pantoprazole and marijuana from food and drug administration fda, and is updated regularly. Generic drugs usually cost less than the brandname version. Other potential drug interactions with pantoprazole may involve warfarin. Pantoprazole was not detectable volatile oil of black cumin on rheumatoid arthritis in rat models article in phytotherapy research 219. Pantoprazole is metabolized in the liver, primarily by the cyp2c19 and cyp34a isozymes of the cytochrome p450 system. Lack of interaction between pantoprazole and ethanol medscape. Eating grapefruit can inhibit cytochrome p450 34a, slowing metabolism of some drugs eg, amiodarone. Pantoprazole is primarily metabolized by the liver.
Warfarininduced raised international normalized ratio is. A book called drug interactions went to press 35yrs ago and contained a few hundred drug interactions today, the book is called drug interactions analysis and management and contains thousands of interactions hansten and horns drug interactions analysis and management, wolters kluwer health, inc 2008. This emedtv web page discusses these and other potential drug interactions associated with pantoprazole, such as those involving ketoconazole. Pantoprazole and marijuana drug interactions a study of fda. See what the interactions are and for which people. When pantoprazole is taken by people using atazanavir, it can interfere with the effectiveness of the atazanavir. Manufacturer advises administer ketoconazole with an acidic beverage.
Call your doctor right away if you have severe bone pain or are unable to walk or sit normally. Manufacturer advises adjust dose, see ledipasvir with sofosbuvir. Pantoprazole is a proton pump inhibitor ppi that blocks the acidproducing pump in the wall of the stomach. Pantoprazole has weakly basic and acidic properties. Intrinsic muscle activity was monitored before control condition and after drug exposure using a video camera the imaging source europe, bremen, germany at intervals of 24 h. Food medication interactions 19th edition zaneta m pronsky ms rd ldn fada, dean elbe bsc pharm bcpp pharm d, laura finn bcgp fascp, william roberts md phd, keith ayoob edd rd fada, sol epstein md frcp facp on.
Among adults who received highdose methotrexate median dose of 3500 mgm2, range of 5000 mgm2, coadministration of ppis such as omeprazole, lansoprazole, or rabeprazole was identified as a risk factor for delayed methotrexate elimination. Protonix pantoprazole sodium drug interactions pfizer. Patients receiving pantoprazole iv should be converted to po dosing as soon as possible. Pantoprazole is a prescription drug used as a shortterm treatment for gastroesophageal reflux disease gerd its part of a class of medications known as protonpump inhibitors ppis and is.
The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of. Pantoprazole was not detectable pantoprazole is a proton pump inhibitor that decreases the amount of acid produced in the stomach pantoprazole is used to treat erosive esophagitis damage to the esophagus from stomach acid caused by gastroesophageal reflux disease, or gerd in adults and children who are at least 5 years old. This product is available in the following dosage forms. Glucose is a source of energy, and all the cells and organs in your body need glucose to function properly. Pantoprazole is a proton pump inhibitor that decreases the amount of acid produced in the stomach. The medicine is in a class of drugs known as anticoagulants blood thinners. Nov 09, 2018 glucose is a form of natural sugar that is normally produced by the liver. Pantoprazole and marijuana drug interactions a study of. Pantoprazole sodium sesquihydrate is freely soluble in water, very slightly soluble in phosphate buffer at ph 7. Diarrhea, abdominal cramping, fever, and bloody stools should be reported to health care professional promptly as a sign of pseudomembranous colitis.
207 910 772 1245 378 495 931 657 993 655 756 173 1295 674 29 1145 1425 1280 224 627 976 545 808 1443 574 1472 1456 1160 75 447 985 910 1375 304 1409 601